Honestly... they're not that bad. The only issue I've had with the menus/inventories is that sometimes it appears the mouse pointer doesn't recognize the areas it can activate. That is most likely a scaling issue between different resolutions, which is relatively common in a lot of these games.
Now, let's talk negative stuff about the game. It's important in order to avoid JUST overhyping it:
* You still look ridiculous when jumping and running in third person view. The combat and stuff looks great, but those two still look like shit.
* For some reason this game has inherited something from former Bethesda games. CTDs with no error message. Use the quicksave. Alot.
* Over my 15 hours (so far) I've seen two creatures 'fall through the world' when dying. Both were mudcrabs. Annoying that it still happens.
* I have seen a wolf do a handstand. Well, pawstand. Much rarer than Fallout3/NV though. Impossible to completely avoid I guess.
* Companions are a bloody nuisance at times. Most times, in fact. I've started using them as disposable distractions/decoys while I line up killshots. They'll trigger floortraps INCESSANTLY and never bloody learn where you DON'T want to step. I.E the same fucking trap ntheen times.
That's pretty much it, so far. I couldn't find anything else to bitch about. I think the game looks absolutely -stunning- graphics wise. (Yes, there's shitty textures some places, but considering just how much of the world is rendered at once depending on where you are, I can bloody understand that.) The vistas are gorgeous and the world is marvelously designed to really feel alive, rugged and real. There's real lives going on in the villages and the NPCs have so far -never- given me the multiple voices in one conversation thing from Oblivion, and I've yet to hear the same voice actor talk to him/herself.
The most amazing thing is how they react to the world changing. Immediate changes like a dragon killed in/near town will cause a flock of them to come admire you and the kill. Smaller events will be reacted to as well. You'll be shown to your room in some inns, quest npcs will guide you where you need to go and everything just feels right.
Once I've played a for a few more days, I'll try to get some mini-reviews up of the various faction questlines. I've finished the Dark Brotherhood one so far (except it doesn't 'end' as such. You apparently get almost infinite kill contracts afterwards, but they're not exactly 'epic' in nature.) and will be going for more.
Oh, and dragons. You'll just -never- find it getting old to stab them in the face with daggers, or whatever killing method you prefer.