So the discovery that what we thought was one kind of synapse is actually several won't require additional resources to simulate in a hypothetical uploaded brain?
I think we have a different way of thinking about things. To me, it isn't a setback, because we were wrong before, and now that we have discovered differently, are closer to aligning our understanding with the objective reality that exists whether we understand it or not.
As for integrating nerve impulses into machinery, that doesn't help at all. It's the meat that's doing all the heavy lifting in that arrangement; the converse requires entirely different engineering.
A hundred years ago, people regularly died from what we would call a minor infection today, because they didn't have antibiotics. Fifty years ago, people considered color television sets the size of a small car the height of technology. I think I have reason for optimism.