As for anti-foreigner, that would definitely be interesting from my POV as the player of an Intaki immigrant - though I am sure my character will thrive even with an ethnically oriented culture at play.
Anti-foreigner implies more like people from different culture, rather than peoples of different ethnicity. Although, I agree, that will be slight discrimination towards people of different ethnicity, since they are visually associated with foreigners, and, obviously, will have to prove their "Caldarity" to the hosts, while traditional Caldari could be free from such procedure.
https://wiki.eveonline.com/en/wiki/Caldari Here it is said, that Caldari are not xenophobic, but are very protective of their way of life and tolerate only those foreigners that stick to the rules. Remembering that old story, that Caldari executed Gallentean, who walked to temple with footwear on, I imagine to myself strict rules of Caldari etiquette, that we as players simply omit to play, because they are not defined, but we imply our characters follow them, and, naturally, foreign characters don't follow. It includes behavior, gestures, dressing manner, usage of honorific and general manner of speech. For example, Caldari host can be offended by certain types of expressive or revealing gallentean dresses, that are considered pretty much formal in Federation, or Amarrian cleric, hiding his face from host under the hood, or maybe Minmatar, who lacks certain detail of wardrobe, or wears too many trinkets. Amarrian holders, denying paying respect to hosts, too loud minmatars, and gallenteans, who believe that they are free to do and speak whatever they want, this all could be rather offending to Caldari.
On one hand, there should be open Caldari establishments, that Caldari hosts use to get more profits from foreigners, but on other hand, there should be "no-foreigner" policy ones as well, for those residents, who can't stand foreign "insults" to Caldari culture. Where in first ones it would be not polite to ask foreigners to follow Caldari traditions, while in second, a guest who neglects to follow set norms will be either asked to leave, or bring apologies and change behavior.