Aside from RP goals, which are less well-defined, and which I won't share OOC anyway, some of the more practical in-game goals:
Buy and outfit an Ashimmu
check
Get enough LP to buy and outfit Apoc Navy Issue
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Own a billion isk liquid
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Corner a market
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Get 1 million Faction Warfare LP
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Get 100 solo kills without a carrying a point in my Crusader
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Get 1000 kills with my Crusader
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Get kills in my Crusader under gate-gun fire
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Get kills in one of my dozens 'idiot-fit' ships
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Kill a standard dual-prop Dramiel with my Crusader
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Put up and maintain a POS
check (and boring.....)
Run T2 production lines
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Establish artificial price level for one particular product in Domain
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Become sole supplier of laser crystals for Domain
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Try PI
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Try wormhole operations
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Participate in Alliance Tournament
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Try nullsec sov warfare
check (boring+!!!!!!)
I once had a similar goals, to own and fly all ships, but at some point having/flying another ship doesn't give the same kick as it did before. I have the skills to fly most ships fairly well (bar a few t3 and capitals), but I find the ships become just a few more pixels in you hangar unless you have very particular need to fly them.
Incidentally, I like Empire wars (and FW) because it gives me better opportunities to switch a ship into exactly that what I need for the particular situation. For example, I don't think I've ever flown a Megathron, even though I have good skills for it. Haven't seen a situation yet where I could use it.
As you can see, a lot of 'practical' goals have either been fullfilled or lost their meaning, which leads to more focus on enjoying the actual playing instead of running after some carrot, which in turn can lead to 'bittervet' syndrome.