Interestingly, it's never really been a problem for me. As a writer, I've made and explored a lot of characters, many of them deeply unpleasant individuals. The Robespierre-quoting cockney terrorist wanting everything to burn and the sadistic torturer alien particularly stick in my mind.
Repentence is not someone I'd get on with. Her pro-slavery outlook, total selfishness and a host of other traits are ones that we do not share, but I find her fascinating to play. I'm also aware that she's come a very long way from the naive cuddleslut she used to be, but that's just been natural evolution. That said, it's come in large part because I'm a total sadist who puts their characters through hell just because it amuses my twisted mind.
Joining Veto is probably the one real example where IC and OOC interests conflicted - PRETA more or less shut down, but Mortis had no interest in working with Guristas and, had it been up to him, would probably have just buggered off to Curse to continue working with the Cartel. The player wanted to keep up with the old gang and do more of the same, though, so I concocted 'orders from above'.
For the most part, though, I've been content to just let things shift as they may. Part of that may be my historically massive swarm of alts (I was running three accounts for a while), so I really could have my cake and eat it.