So offhand I'm thinking of two programs: the first being a relationship/sex advice call/write in style show with 1-3 people hosting (preferably different backgrounds: a doctor, a therapist type, and some kind of every day Joe type for plebeian humor), and the second being a political round table environment where one host presents current events topics to a panel of four diverse guests who discuss and generally present some moderate wisdom and unique insight on all sorts of topics.
These shows will probably be twice a week for an hour or two.