I guess we can say goodbye to solo industry, or solo play in general with that kind of things.
There's a wonderful game called X3: Rebirth coming out if you want solo play. I kinda like the fact their doing the "Multiplayer" part of the "Massively Multiplayer Online Game".
Ignoring that Multiplayer just means more than one human is playing the same game:
What is the cost to wardec Goonswarm again ? 800M isk was it ?
ok, Corporation A, wants to control the hi-sec Customs offices in constellation X. Those customs offices are owned by Goonswarm. Corporation A decides to spend the 800+ M isk to wardec, take down, and replace those customs offices. How long do those offices need to stay up, in order to recover that 1Bn or so investment ?
Goonswarm ignore that wardec, observe what the war was about, then, declare on Corporation A. Because of size, it only costs them 100M to wardec.
Corp A, loses their investment, and the customs offices didn't even come close to paying off, before control was lost again.
They cannot justify the expense of trying again, other than for e-peen.
And that's a situation that will be apparent for anyone else considering looking at the customs office control.
It hugely favours larger entities over small entities. The rational, financial decision is to just let Goonswarm or other large entity control the customs offices, and deal with the fiddlyness and expense of rocket launching instead.
So... yeah, solo/small groups of characters, are squeezed out.
No need to be a jerk and mention X3.
It necessitates these different entities to band together and find a location they can conduct their PI work from. No longer being able to safely/reliably farm highsec means more coordination work needs to be put in. Conversely, larger entities that can afford the cost will be willing to defend and setup POCOs.
The issue with POCO profitability is that it is so easy to use different ones elsewhere, thus there is no user pressuring. Unless you live in a one or two system alliance territory, but even then they might simply import elsewhere. If the general users had to go to 'POCO hubs', where they can reliably access their materials, profitability will shoot up insanely high.
A billion or two investment in that case might not be out of the question, if you have enough people regularly using your services.