I've always found the concept of, "If you do business in the Khanid Kingdom, Amarr Empire or Ammatar Mandate you support slavery and Minmatar want nothing to do with you," As a bit requiring of credulity when Kaalakiota and Ishukone especially have numerous assets in Republic space and the Federation has had a century-long standing FTA with the Empire signed at Girani-Fa.
Economic and political reality has almost always trumped idealistic notions, but the ability to engage in pragmatic realpolitik in RP as in: This is a mutually advantageous business arrangement we're entering into; seems to be less preferred over the more black and white, "These are the good guys and these are the bad guys."
As such, I think the major hurdle with a project like this is less to do with the functional aspects of finding a rationale as to why Caldari would invest or do business in the Republic (They already do to some extent) but rather in effective perception management and the undermining/marginalization of positions against the concept in RP.