The thing I'm most curious about is how they're going to handle death.
WoD vampires are even more vulnerable than capsuleers. Sure, there are only a few things that do them permanent damage, but fire and sunlight are serious and universal banes and you can get put right into the vampire equivalent of a persistent vegetative state with a shotgun blast or two. Furthermore, the WoD is full-- full-- of stuff that can write your character a one-way ticket to that great coffin in the sky (heh) in a matter of seconds, starting with another vampire (and you can be damned sure that other vampires know exactly how to make sure you won't be getting up again).
And they only get one body.
Working around all that is going to require 1. the most ruthless character-death system to exist in an MMO, 2. some credulity-stretching narrative license, or 3. a serious rewrite of how vampires get offed.
A partial solution might be to allow people to keep their "experience," or whatever, from character to character, allowing the creation of a new, equally experienced character each time the last one permanently snuffs it. But that's still going to result in tears, petitions, and canceled subscriptions.
As much as CCP wants this to focus on politics and social interaction (as it should), combat is going to come into this somewhere. Exactly how they approach that is going to be incredibly important to how this game comes together.
If they do a good job, I may have some hard decisions to make: I love Eve, but VtM is the first game I ever got into that wasn't sword and sorcery (like many, I started with D&D). If they include the Followers of Set, that decision's going to get even harder; it'll be damned difficult to resist the temptation to dust off that conniving old serpent Moebius and see whether I can talk my way onto the city Primogen all over again.